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Welcome to the Ion Channel and Receptor Biology Group

Ion channels generate electrical current signals in the nervous system and are central to our perception of ‘Who We are’. Anomalies in their function often lead to disastrous consequences in living organisms. In humans, more than 50 channelopathies, e.g. epilepsy, cystic fibrosis, cardiac arrhythmia etc., have been described which are due to mutations in ion channels and receptors that change their function. Ion channels are one of the major molecular targets of commercial drugs. My research interest has been largely focused on the structure-function of ion channels and their implications in human pathophysiological conditions. My lab employs ‘single channel’ and ‘whole-cell’ patch-clamp electrophysiology, stochastic data analyses, kinetic modeling, protein engineering and experimental data-guided molecular simulation tools to understand ion channel structure and function.